Drugs that target G-protein coupled receptors or GPCR account for near 30% of the global market share of therapeutic drugs. The high interest and large market share are because of how important GPCRs are in many diseases. Right now, there are over 2000 different mutations in 55 GPCR genes that have been characterized and linked to over 60 human diseases. Based on how those mutations can change the functions of GPCRs, mutations can be divided into gain-of-function mutations and loss-of-function mutations.

–About me–

I am a computational chemist in the pharmaceutical industry. I created the Mole Man Chem channel to explain some basic medicinal and biochemistry concepts because I believe the best way to relearn a concept is through teaching.

Feel free to email me with any questions at molemanchem@gmail.com

–Video lists–
Medicinal chemistry playlist: https://www.youtube.com/watch?v=SNYb7E9oWO4&list=PLK7JMguNBXJOefOP5WFy9AUIsKReOD91I&t=0s

Drug discovery explained playlist: https://www.youtube.com/watch?v=0rMcD-_dGDI&list=PLK7JMguNBXJOBMkSsluR2926rtYLfRO7m

0:00 Overview
0:57 GPCR
4:52 GPCR mutations
8:25 GPCR mutation-caused disease treatment

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This video “G-Protein Coupled Receptors (GPCRs)” is part of the Lecturio course “Biochemistry” ► WATCH the complete course on http://lectur.io/gproteinreceptors

► LEARN ABOUT:
– G-Protein Coupled Receptors
– GPCRs and G-Proteins
– β-adrenergic receptor signaling – Creation of the second messenger

► THE PROF: Kevin Ahern received his B.S. and M.S. degrees from Oklahoma State University, and a Ph.D. in Biochemistry from Oregon State University. Currently he is working as professor of biochemistry and biophysics at Oregon State University. He is also a co-author of the popular biochemistry textbooks, “Biochemistry Free and Easy”.

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G-protein coupled receptors (GPCRs) are an attractive drug target; however, not enough is known about their structure, as they are too unstable to isolate and purify. This medical animation highlights the important role they play in many physiological functions and diseases.
Hosted on the homepage of the Heptares website, the animation introduces a new method developed by Heptares, of maintaining the structure of GPCRs following their isolation. This method allows for the more effective assessment of drug candidates, highlighting how this technology may be used to develop new treatments for various diseases, including Alzheimer’s disease and cancer.
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Learn about how g protein coupled receptors work in the cell membrane. Created by William Tsai.

Watch the next lesson: https://www.khanacademy.org/test-prep/nclex-rn/nervous-system-phy/rn-biosignaling/v/enzyme-linked-receptors?utm_source=YT&utm_medium=Desc&utm_campaign=Nclex-rn

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aspects of Cell signalling
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