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Circulating vitamin D level and mortality in prostate cancer patients: a dose–response meta-analysis

https://pubmed.ncbi.nlm.nih.gov/30352424/

Results

Higher vitamin D level could reduce the risk of death among prostate cancer patients.

Association of circulating 25-hydroxyvitamin D level with prognosis of prostate cancer

We conducted a dose-response meta-analysis

Seven eligible cohort studies, n = 7, 808

The summary HR of prostate cancer-specific mortality

An increment of every 20 nmol/L in circulating
vitamin D,

(20 nmol/L = 8 ng/ml)

HR = 0.91, (P = 0.002)

Every 20 nmol/L increment in 25-hydroxyvitamin D level was associated with a 9% lower risk of,

all-cause mortality,

and prostate cancer-specific mortality.

Pooled HRs were stable and not obviously changed by any single study.

No evidence of publications bias was observed.

This meta-analysis suggested that higher 25-hydroxyvitamin D level was associated with a reduction of mortality in prostate cancer patients,

and vitamin D is an important protective factor in the progression and prognosis of prostate cancer.

Risk estimates with 95% CI for the association between 25(OH)D and prostate cancer-specific mortality.

Mechanism

Vit D, could cause cell cycle arrest,

and induce apoptosis,

inhibiting cell proliferation in several prostate cancer cell lines

Protection from prostate epithelial cell lines from oxidative stress

Will supplements help?

Effect of Vitamin D3 Supplements on Development of Advanced Cancer: A Secondary Analysis of the VITAL Randomized Clinical Trial

https://pubmed.ncbi.nlm.nih.gov/33206192/

4,000 units (100 micrograms) day

24 of 44 subjects (55%) showed a decrease in the number of positive cores or decrease in Gleason score

Prostate cancer in black Americans

https://aacrjournals.org/cancerrescommun/search-results?page=1&q=African%20American%20Prostate%20Cancer%20Displays%20Quantitatively%20Distinct%20Vitamin%20D%20Receptor&SearchSourceType=1

Cancer prevention

https://www.cancer.gov/about-cancer/causes-prevention/risk/diet/vitamin-d-fact-sheet

Numerous epidemiologic studies have shown that higher intake or blood levels of vitamin D are associated with a reduced risk of colorectal cancer
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PCRI’s Executive Director, Mark Scholz, MD, describes vitamin D’s relevance in prostate cancer management and gives advice for coordinating with your physician to find the appropriate dose if your vitamin D levels are low.

0:01 Vitamin D is often brought up in the context of prostate cancer; most likely because men undergoing hormone treatments experience accelerated calcium loss from the bones (osteoporosis). Adequate vitamin D levels ensure the optimal absorption of calcium, and typically men on hormone therapy should be taking calcium and vitamin D together before bedtime.

0:36 Like with many other supplements, there has been some hype regarding what vitamin D is capable of and a lot of questionable claims about dosing. Actually, there is no universal dosage and the massive amounts that are being touted by the megadose trend are not useful. The appropriate course of action is to have your vitamin D level checked annually by a physician. About 25% of men in their 60s, 70s, and 80s have a vitamin D level below 30 ng/ml which is considered low. If your vitamin D level is low it’s advisable to take about 1,000-2,000 units per day, and then retest about 3-4 months later to make sure that levels are not too high or low. Period retesting is also recommended.

2:13 Ensuring a proper level of vitamin D is essential for men on hormone therapy to help prevent any unnecessary bone loss. Rather than taking megadoses, men should have their vitamin D levels checked, coordinate with their physician, and decide how much to take based on their individual situation.

Don’t know your stage? Take the quiz: Visit http://www.prostatecancerstaging.org

To learn more about prostate cancer visit http://www.pcri.org

To download the free Staging Guide visit http://www.pcri.org/prostate-cancer-s…

Who we are:

The Prostate Cancer Research Institute (PCRI) is a 501(c)(3) not-for-profit organization that is dedicated to helping you research your treatment options. We understand that you have many questions, and we can help you find the answers that are specific to your case. All of our resources are designed by a multidisciplinary team of advocates and expert physicians, for patients. We believe that by educating yourself about the disease, you will have more productive interactions with your medical professionals and receive better-individualized care. Feel free to explore our website or call our free helpline at 1 (800) 641-7274 with any questions that you have. Our Federal Tax ID # is 95-4617875 and qualifies for maximum charitable gift deductions by individual donors.

The information on the Prostate Cancer Research Institute’s YouTube channel is provided with the understanding that the Institute is not engaged in rendering medical advice or recommendation. The information provided in these videos should not replace consultations with qualified health care professionals to meet your individual medical needs.

#ProstateCancer #Prostate #MarkScholzMD
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