Researchers from Mayo Clinic have published a new study on the gut microbiome and C. difficile in the journal Science Translational Medicine: http://stm.sciencemag.org/content/10/464/eaam7019. Using a novel mouse model, the researchers found that a subset of patients with diarrhea may be susceptible to C. difficile infection as a result of deleterious changes in their gut bacteria and increased availability of amino acids, the favored food source for the pathogen C. difficile. The researchers also found that fecal microbiota transplant or dietary restriction can decrease amino acids availability and prevent C. difficile infection.
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Physicians with the Beacon Center for Infectious Diseases – specialists in diagnosing and treating infections – discuss a common health care associated infection called Clostridium difficile or “C. diff.”
C. diff can be a serious infection that causes symptoms ranging from diarrhea to life-threatening inflammation of the colon. It’s linked to an estimated 14,000 deaths in the U.S. each year. The infection most commonly affects people staying in a hospital or long-term health care facility and usually occurs after the use of antibiotics.
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