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Circulating vitamin D level and mortality in prostate cancer patients: a dose–response meta-analysis

https://pubmed.ncbi.nlm.nih.gov/30352424/

Results

Higher vitamin D level could reduce the risk of death among prostate cancer patients.

Association of circulating 25-hydroxyvitamin D level with prognosis of prostate cancer

We conducted a dose-response meta-analysis

Seven eligible cohort studies, n = 7, 808

The summary HR of prostate cancer-specific mortality

An increment of every 20 nmol/L in circulating
vitamin D,

(20 nmol/L = 8 ng/ml)

HR = 0.91, (P = 0.002)

Every 20 nmol/L increment in 25-hydroxyvitamin D level was associated with a 9% lower risk of,

all-cause mortality,

and prostate cancer-specific mortality.

Pooled HRs were stable and not obviously changed by any single study.

No evidence of publications bias was observed.

This meta-analysis suggested that higher 25-hydroxyvitamin D level was associated with a reduction of mortality in prostate cancer patients,

and vitamin D is an important protective factor in the progression and prognosis of prostate cancer.

Risk estimates with 95% CI for the association between 25(OH)D and prostate cancer-specific mortality.

Mechanism

Vit D, could cause cell cycle arrest,

and induce apoptosis,

inhibiting cell proliferation in several prostate cancer cell lines

Protection from prostate epithelial cell lines from oxidative stress

Will supplements help?

Effect of Vitamin D3 Supplements on Development of Advanced Cancer: A Secondary Analysis of the VITAL Randomized Clinical Trial

https://pubmed.ncbi.nlm.nih.gov/33206192/

4,000 units (100 micrograms) day

24 of 44 subjects (55%) showed a decrease in the number of positive cores or decrease in Gleason score

Prostate cancer in black Americans

https://aacrjournals.org/cancerrescommun/search-results?page=1&q=African%20American%20Prostate%20Cancer%20Displays%20Quantitatively%20Distinct%20Vitamin%20D%20Receptor&SearchSourceType=1

Cancer prevention

https://www.cancer.gov/about-cancer/causes-prevention/risk/diet/vitamin-d-fact-sheet

Numerous epidemiologic studies have shown that higher intake or blood levels of vitamin D are associated with a reduced risk of colorectal cancer
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